Erkan Yilmaz
Ankara University, Turkey
Title: The role of glutamine transport and metabolism in the insulin resistance and endoplasmic reticulum stress
Biography
Biography: Erkan Yilmaz
Abstract
Glutamine metabolism in insulin resistance mechanisms are not well understood yet. In some cases glutamine can be used as fuel, levels of glutamine in tissues and circulation can be effective in the regulation of cellular responsiveness to insulin and cellular metabolism. We aimed to reveal a possible relationship between glutamine metabolism and endoplasmic reticulum stress in insulin resistance. Fat and liver tissues of Ob/Ob mice, increased endoplasmic reticulum stress, increased insulin resistance and decreased glutamine transporter (ASCT2) and glutamine signaling (mTOR, LAT1, GCN2) observed. Glutamine is an important metabolite in the regulation of energy requirements and cellular hemostasis in the cell. And in insulin resistance in the process of adaptation to the new use of glutamine as a fuel, one of significant digits is likely to be.